| This analytic data file set consists of eight files generated for an epidemiologic case-control study of multiple myeloma among a cohort of 115,143 workers employed at the Hanford, Los Alamos National Laboratory, Oak Ridge National Laboratory, and Savannah River sites and hired before 1979, by Steve Wing. |
| This study was requested by NIOSH because of previous reports of associations of multiple myeloma with radiation exposures of workers at the Hanford site. The new study was intended to include more cases of disease, better evaluation of radiation doses, and measurement of other occupational exposures not available in the Hanford studies. The 98 multiple myeloma deaths and 391 age-matched controls were followed
for vital status through 1990. Hanford workers were followed through only 1986. Information on prior work history, smoking, medical x-rays, and exposure to physical and chemical agents was derived from personnel, medical, industrial hygiene, and health physics records. |
| The study compared exposure histories of cases and controls to investigate whether certain occupational exposures were relatively more common among cases. Potential exposures to a variety of chemical and physical agents that might be causes of multiple myeloma were investigated, including solvents, metals, welding fumes, asbestos, and ionizing and non-ionizing radiation. With the exception of external penetrating radiation, for which most longer term workers had at least some badge data, information of exposures to specific chemical and physical agents was not sufficient to assign a quantitative exposure estimate or even to determine with a high degree of certainty whether or not a worker had been exposed. |
| Total cumulative radiation doses were similar between cases and controls. However, doses received at ages 45 years and older were associated with an average 7% per 10 mSv (1 rem) increased risk of multiple myeloma, adjusted for age, race, sex, facility, period of hire, birth cohort, monitoring for internal radionuclide contamination, and external radiation received prior to age 45 years. The 95% confidence limit for this estimate was 1-13%. For exposure at ages 45 years and older, the odds ratio for workers with cumulative doses of 50 mSv (5 rem) or greater compared with workers with cumulative doses of less than 10 mSv was 4.34 (95% CI 1.46-12.90). |
| MFMM98A1_d1 includes annual external radiation (mrem) dosimetry data from all study facilities standardized in a common format by year. |
| MFMM98A1_d2 is the basic case and control file that contains demographic data, employment dates, personnel, and occupational health variables used in the analysis. |
| MFMM98A1_d3 contains one record for each individual worker and constitutes a qualitative assessment of exposures to select chemical and physical hazards for the study population. |
| MFMM98A1_d4 includes employment dates at each of the study sites. |
| MFMM98A1_d5 gives counts of internal monitoring records lagged 5, 10, 15, 20, and 25 years from the index date of the age at risk. Counts of Pu, SR, tritium, in vivo measurements, and nose counts are included. |
| MFMM98A1_d6 documents medical x-rays in occupational health department records at the four DOE sites. |
| MFMM98A1_d7 contains one record for each individual worker of coded data abstracted from occupational health records at the four DOE sites. |
| MFMM98A1_d8 contains coded data abstracted from personnel records. |
