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Study Name: Hanford Cohort Mortality Study, 1993
Cohort Size: 44,156
Races: White, non-white
Sexes: Female, male
Diseases: Cancer Mortality
Earliest Exposure: 01/01/1944
Latest Exposure: 12/31/1989
Follow-Up: 12/31/1989
Exposure Type: External and Internal Radiation
Exposure Agent: Gamma ray, X-ray, neutron, tritium, plutonium, americium, cesium, curium, europium, promethium, strontium
Covariate: Last Social Class, Longest Held Social Class
Sites: Hanford Site
Description:
This analytical data file set consists of three files for the updated cohort mortality study of operations workers initially employed during 1944 to 1978 at the Hanford Site by Ethel Gilbert, et al., published in Health Physics in 1993.
This study continues to examine the relationship between occupational radiation exposure among Hanford workers and mortality from specific causes. The files used for this paper have been updated and refined since the 1989 publication. The study showed that both male and female workers continue to exhibit a strong healthy worker effect, with death rates from most causes substantially below those of the general U.S. population. Comparisons by level of radiation exposure within the Hanford worker population provided little evidence of a positive correlation between cumulative radiation exposure and mortality from leukemia or from all other cancers combined.
The three analytic files in the HFI89A01 data file set, constructed using the IARC protocol, pertain to 44,156 Hanford operations workers initially employed at Hanford between 1944 and 1978. The first file, HFI89A01_d1 (IARC89_1), with one record per individual, contains demographic, work history, vital status, external dosimetry, and internal deposition data. Mortality data are provided for deaths occurring outside Washington State between 1944 and 1986 and deaths occurring in Washington between 1944 and 1989, inclusive. Internal deposition data include the radionuclide symbol and the year of first plutonium deposition. The second file, HFI89A01_d2 (IARC89_2), contains external exposure data for the years 1944 through 1989. The dosimetry data include doses received while performing construction work at Hanford as well as occupational doses received off-site at other facilities. There is one record for each year of exposure data for each of the 37,012 monitored workers. The third file, HFI89A01_d3 (IARC89_3), contains additional data related to internal exposures, off-site exposures, and cause of death. There is one record for each worker.
Comparisons with the U.S. general population included a cohort of 42,070 white workers. There were 9,452 deaths identified, and death certificates were obtained for 9,285 (98.2%) of these deaths. Dose- response analyses included 32,643 workers (24,672 males and 7,971 females) who were monitored for external radiation and employed for at least 6 months between 1944 and 1985. Vital status was ascertained through 1986, the study end date. There were 6,286 deaths identified, and death certificates were obtained for 6,200 (98.6%) of these deaths. Both types of analyses included deaths through December 31, 1986.
Workers at the Hanford Site were involved in a variety of activities that resulted in their exposure to radiation, including reactor operations, chemical separation of reactor fuel to obtain plutonium, treatment and storage of hazardous waste, and biological and engineering research. Personal dosimeters (film or thermoluminescent) have been used since 1944. Bioassay programs to detect exposures to internally deposited radionuclides, primarily transuranics, also were initiated in 1944. Dose estimates resulting from these monitoring programs appear in this data file set. Annual whole-body doses to penetrating external radiation are presented in units of millisieverts. Quality factors of 10 for fast neutrons, 3 for slow neutrons, and 1 for photons and electrons were used in the conversion of exposure to dose. Internal exposure data were collected and evaluated for all individuals who worked in locations where there was a potential for intake of radioactive material (transuranics).

Citations Associated:
Gilbert, E. S. (1989). Issues in analysing the effects of occupational exposure to low levels of radiation. Statistics in Medicine, 8(2), 173–187. https://doi.org/doi.org/10.1002/sim.4780080205
Gilbert, E. S., Fix, J. J., & Baumgartner, W. V. (1996). An approach to evaluating bias and uncertainty in estimates of external dose obtained from personal dosimeters. Health Physics. https://doi.org/10.1097/00004032-199603000-00003
Gilbert, E.S. (1988). The Hanford study: issues in analysing and interpreting data from occupational studies in: health effects of low dose ionizing radiation-recent advances and their implications.
Gilbert, E.S., Buchanan, J.A., Holter, N.A. (1992). Description of the process used to create 1992 Hanford mortality study database. Pacific Northwest Laboratory.
Gilbert, Ethel S., Omohundro, E., Buchanan, J. A., & Holter, N. A. (1993). Mortality of workers at the hanford site: 1945-1986. Health Physics. https://doi.org/10.1097/00004032-199306000-00001
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