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Data File: MDSMRA01


 
Data Files (1):
Study Name: Cohort Mortality Study of White Males Employed at the Mound Plant
Cohort Size: 4,697
Races: White
Sexes: Male
Diseases: Cancer and Non-Cancer Mortality
Earliest Exposure: 04/01/1942
Latest Exposure: 12/31/1979
Follow-Up: No data available.
Exposure Type: No Exposure Monitoring Data
Exposure Agent: Polonium-210, Plutonium-238
Covariate: Education, State of Death
Sites: Mound Plant
Description:
This analytic data file set consists of one file generated for a cohort mortality study of white males employed at the Mound Plant by MG Reyes, et al., published as a LANL Report.
A cohort mortality study of workers was conducted to test for an association between mortality and employment at the Mound Plant. The study examined differences in mortality for workers at the plant during its polonium-210 era (1943 to 1959) and for its plutonium-238 era (1960 to 1980) by computing period-specific SMRs based on U.S. rates. The analysis focused on 4,697 white and presumed white males who were employed between April 1, 1942, and December 31, 1979, at the Mound Plant. SMRs of 96 were observed for all causes and for all cancers for the study period (1943 to 1979). No SMR was significantly greater than 100 for these workers. A significantly elevated SMR for lung cancer (SMR = 204, 90% CI = 140, 290) was observed for workers employed during World War II (1943 to 1945). Similar results were noted for all causes of death, all cancers, cancer of the rectum, non-malignant respiratory diseases, and all injuries during this time period. SMRs for these causes of death during the polonium era, but after World War II, were not elevated. No elevated SMRs were observed during the plutonium era. A very strong healthy worker effect was observed for workers in the plutonium era, although the length of follow-up for these workers was relatively short.
The single analytic file, MDSMRA01_d1, in this data file set contains demographic and vital status data for 4,697 white males and presumed white males who were employed between April 1, 1942, and December 31, 1979. Not included in the analytic file are workers employed less than 30 days during this period, workers with unknown birth dates, and workers with both unknown hire and termination dates. No exposure data are included in the file.
Vital status was determined for 97.6% (4,588) of the workers in this file. Death certificates were obtained for 97% (803) of the known deaths. Causes of death were coded to ICDA8. Sex, race, education level, and dates of employment are also included in the data.
The Mound Plant has been a center for the separation, chemistry, and metallurgy of polonium-210 and processing of plutonium-238 for heat sources. Other small research projects involved radium and thorium. Workers could have been exposed to external and internal sources of radiation; however, this analysis did not examine exposure data.

Citations Associated:
Reyes, M. Wilkinson, G.S., Tietjen, G.L., Wiggs, L.D., Galke, W.A. (1991). Mortality among workers at the Mound facility: a preliminary report. Los Alamos National Laboratory.
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