| This analytic data file set consists of one file generated for a case-control study of white male nickel workers at the Oak Ridge K-25 Facility by Donna Cragle, et al., published in IARC Scientific Publications. |
| This study examined mortality patterns in a group of 814 workers potentially exposed to nickel powder because previous studies of workers at nickel refineries had shown excesses of lung and nasal sinus cancers. Between January 1, 1948, and December 31, 1953, the ORGDP (now known as the K-25 Facility) employed over 800 white males in the manufacture of "barrier" material for nuclear weapons. This process required the use of metallic nickel powder. For the study, a comparison group of 7,552 white males employed for at least 1 day at K-25 between January 1, 1948, and December 31, 1953, and who had no indications of occupational involvement in the production of barrier material was selected. Mortality rates in the nickel workers and non-nickel workers were compared with each other and with those of U.S. white males. There was no evidence of increased mortality due to lung cancers or nasal sinus cancers in the nickel workers. Increases, not statistically significant, in mortality due to cancers of the buccal cavity, pharynx, and digestive system were observed in the nickel worker group when compared to the non-nickel worker group. |
| The single analytic file, ORK25A01_d1 (K25EVER1), contains one record for each of the 8,378 individuals in the cohort that includes the nickel workers and the comparison group of non-nickel workers. Vital status was ascertained for 100% of the cohort through December 31, 1977, which allowed at least 24 years of follow-up for each individual. There were 137 deaths identified in the nickel worker group and 1,920 deaths in the comparison group. Death certificates were obtained for 97% of the total number (2,057) of deaths. |
| Radiation monitoring data were not used in this study |
