| The analysis file, prepared for studies by H.D. Wooten and Donna Cragle, consists of seven files containing questionnaire data administered through interviews with K-25 workers who were employed in the gas centrifuge process and K-25 workers who were not involved in this process. These data were analyzed by conducting a case-control study. |
| K-25 workers who were employed in the gas centrifuge process were the focus of an interview study completed by Cragle et al. The study was conducted to determine the incidence rate of cancers and illness symptoms that could be related to epoxy resin and solvent exposures that were prevalent in this process. A total of 263 workers who were judged to have worked the closest to the process for the longest period of time were interviewed, as well as 271 other employees who were at the plant during the same era of time but did not work in the centrifuge process. |
| The centrifuge workers and the non-centrifuge workers had similar overall cancer incidence rates. However, the centrifuge workers reported five incident bladder cancers since beginning to work in the centrifuge process versus none reported in the non-centrifuge group. The centrifuge workers also reported significantly more rashes, dizziness, and numb or tingling limbs during employment, which are all symptoms of high solvent exposure. |
| The analysis file consists of seven files containing identifying data from interviews with centrifuge workers ORK25A03_d1 (CENTRIF.ID), and questionnaire data ORK25A03_d2 through ORK25A03_d7 (CENTRIF.Q2, CENTRIF.Q3, CENTRIF.Q4, CENTRIF.Q5, CENTRIF.Q6, and CENTRIF.Q7). |
| Exposures of interest in context of operations conducted at the facility: One of the epoxy resins used in the early years of the process was potentially a bladder carcinogen, but none of the workers with bladder cancer had jobs that required routine, hands-on work with the material. A specific causative agent for the increase in bladder cancer was not identified. |
