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Data File: ORX10A03


 
Data Files (1):
Study Name: Cancer Case-Control Study at Oak Ridge National Laboratory (ORNL)
Cohort Size: 1,425
Races: White, Non-White
Sexes: Males
Diseases: Cancer Mortality
Earliest Exposure: 06/01/1943
Latest Exposure: 12/31/1977
Follow-Up: 12/31/1977
Exposure Type: External Radiation Monitoring
Exposure Agent: Uranium, Mercury, Beryllium, Lead
Covariate: Autopsy Indicator, Smoking Indicator, Number of Facilities Employed, Year of Hire, Mercury Indicator, Beryllium Indicator, Lead Indicator, Internal Radiation Indicator, Job Title Code, Duration of Employment, First Pay Code, Last Pay Code
Sites: Oak Ridge X-10 (Oak Ridge National Laboratory)
Description:
This analytic data file set consists of one file generated by N.A. Elghany in 1983 for a nested case-control study of cancer mortality of workers at ORNL. The study was conducted for a doctoral dissertation.
The dissertation investigated the relationship between cancer mortality and occupational exposure to radiation among the male employees at ORNL. The study was based on a case-control study nested in a cohort study, using two controls per case. Results indicated that certain subgroups encountered excess cancer mortality risk in relation to radiation exposure.
The single analytic file, ORX10A03_d1 (NAIMA), in this data file set contains data relating to demographics, work history, exposure index rankings, internal hazard codes based on urine bioassay data, vital status, and causes of death. There are 1,785 records in this file, including one record for each of the 423 cases and one record for each of the 846 matched controls (the case-control group), plus one record for each of the remaining 516 workers in the overall cohort. A case was defined to be any male employee who died between January 1943 and December 1977, whose death certificate indicated cancer as the cause of death. Controls were selected from the "population at risk" at ORNL, excluding those who died of cancer. The controls could be either dead or alive.
Vital status was ascertained for 91.7% of the male controls and for 66.5% of the female controls through December 31, 1977, the study end date.
Personal monitoring data were used to place workers into exposure classes; doses were not calculated. Groups based on job title were also formed for the analysis. Smoking histories were obtained for a sample (25%) of the cohort. Exposures to lead, beryllium, and mercury were also considered in the analysis.

Citations Associated:
Elghany, N.A. (1983). An epidemiological study of cancer mortality among workers exposed to occupational low levels of ionizing radiation. University of North Carolina, Chapel Hill. Ph.D. Dissertation.
Ostrouchov, G., Frome, E.L., Kerr, G.D. (1998). Dose estimation from daily and weekly dosimetry data. Oak Ridge National Laboratory ORNL-6945.
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ORISE

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