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Data File: ORX10A05

Data Files (1):

ORX10A05_d1 - Expanded ORNL Cohort

Study Name: Expanded Oak Ridge National Laboratory (ORNL) Cohort Study

Cohort Size: 14,095

Races: Black, White, Other, Unknown

Sexes: Male, Female, Unknown

Diseases: Cancer and Non-Cancer Mortality

Earliest Exposure: 01/01/1943

Latest Exposure: 12/31/1985

Follow-Up: No data available.

Exposure Type: Medical coding

Exposure Agent: Gamma Radiation, Tritium

Covariate: Number of Facilities Employed, First Pay Code

Sites: Oak Ridge X-10 (Oak Ridge National Laboratory)

Description:
This data file set consists of one analytic file containing data for a study of radiation-mortality association among an expanded cohort of workers employed at ORNL during the period 1943 to 1972 by David Barrie Richardson, et al.
This analytical data set, ORX10A05_d1, consists of one file used for a NIOSH-funded study of mortality among workers at Oak Ridge National Laboratory, located in Oak Ridge, Tennessee. This study examined a cohort of 14095 workers hired between 1943 and 1972 who worked at least 30 days at ORNL, for whom there was complete information on gender, race, dates of birth and hire, and who had no more than 2 years of missing annual whole-body dosimetry data from employment at other DOE facilities. The cohort included 3,389 women and 1,071 non-white workers. Vital status had been ascertained for 94% of the cohort in follow-up through 1990, identifying 3,269 deaths. Personal monitoring data for whole-body exposure to ionizing radiation were available for the period 1943 to 1985. Annual whole-body radiation doses were estimated for work-years at ORNL with missing dose data using dose estimates in adjacent time periods and average values for similar workers. Analyses of these data focused on time-related factors which might influence radiation-mortality associations. Positive associations were observed between low-level exposure to ionizing radiation and mortality among workers at ORNL. These associations were larger for doses received after age 45, larger under longer lag assumptions, and primarily due to cancer causes of death.

Description:

This data file set consists of one analytic file containing data for a study of radiation-mortality association among an expanded cohort of workers employed at ORNL during the period 1943 to 1972 by David Barrie Richardson, et al.

This analytical data set, ORX10A05_d1, consists of one file used for a NIOSH-funded study of mortality among workers at Oak Ridge National Laboratory, located in Oak Ridge, Tennessee. This study examined a cohort of 14095 workers hired between 1943 and 1972 who worked at least 30 days at ORNL, for whom there was complete information on gender, race, dates of birth and hire, and who had no more than 2 years of missing annual whole-body dosimetry data from employment at other DOE facilities. The cohort included 3,389 women and 1,071 non-white workers. Vital status had been ascertained for 94% of the cohort in follow-up through 1990, identifying 3,269 deaths. Personal monitoring data for whole-body exposure to ionizing radiation were available for the period 1943 to 1985. Annual whole-body radiation doses were estimated for work-years at ORNL with missing dose data using dose estimates in adjacent time periods and average values for similar workers. Analyses of these data focused on time-related factors which might influence radiation-mortality associations. Positive associations were observed between low-level exposure to ionizing radiation and mortality among workers at ORNL. These associations were larger for doses received after age 45, larger under longer lag assumptions, and primarily due to cancer causes of death.

Citations Associated:
Ostrouchov, G., Frome, E.L., Kerr, G.D. (1998). Dose estimation from daily and weekly dosimetry data. Oak Ridge National Laboratory ORNL-6945.
Richardson, D. B., & Wing, S. (1998). Methods for investigating age differences in the effects of prolonged exposures. American Journal of Industrial Medicine. https://doi.org/10.1002/(SICI)1097-0274(199802)33:2<123::AID-AJIM4>3.0.CO;2-Z
Richardson, D. B., & Wing, S. (1999). Greater sensitivity to ionizing radiation at older age: Follow up of workers at Oak Ridge National Laboratory through 1990. International Journal of Epidemiology. https://doi.org/10.1093/ije/28.3.428
Richardson, D. B., & Wing, S. (1999). Radiation and mortality of workers at Oak Ridge National Laboratory: Positive associations for doses received at older ages. Environmental Health Perspectives. https://doi.org/10.1289/ehp.99107649
Richardson, D.B. (1997). Time-related factors in radiation-cancer associations among workers at Oak Ridge National Laboratory. University of North Carolina, Chapel Hill. Ph.D. Dissertation.
Wing, S., & Richardson, D.B. (1997). Time-related factors in radiation-cancer dose respone: final report. National Institute for Occupational Safety and Health.
Wood, J., Richardson, D., & Wing, S. (1997). A simple program to create exact person-time data in cohort analyses. International Journal of Epidemiology. https://doi.org/10.1093/ije/26.2.395

Citations Associated:

Ostrouchov, G., Frome, E.L., Kerr, G.D. (1998). Dose estimation from daily and weekly dosimetry data. Oak Ridge National Laboratory ORNL-6945.

Richardson, D. B., & Wing, S. (1998). Methods for investigating age differences in the effects of prolonged exposures. American Journal of Industrial Medicine. https://doi.org/10.1002/(SICI)1097-0274(199802)33:2<123::AID-AJIM4>3.0.CO;2-Z

Richardson, D. B., & Wing, S. (1999). Greater sensitivity to ionizing radiation at older age: Follow up of workers at Oak Ridge National Laboratory through 1990. International Journal of Epidemiology. https://doi.org/10.1093/ije/28.3.428

Richardson, D. B., & Wing, S. (1999). Radiation and mortality of workers at Oak Ridge National Laboratory: Positive associations for doses received at older ages. Environmental Health Perspectives. https://doi.org/10.1289/ehp.99107649

Richardson, D.B. (1997). Time-related factors in radiation-cancer associations among workers at Oak Ridge National Laboratory. University of North Carolina, Chapel Hill. Ph.D. Dissertation.

Wing, S., & Richardson, D.B. (1997). Time-related factors in radiation-cancer dose respone: final report. National Institute for Occupational Safety and Health.

Wood, J., Richardson, D., & Wing, S. (1997). A simple program to create exact person-time data in cohort analyses. International Journal of Epidemiology. https://doi.org/10.1093/ije/26.2.395